BDBM1317 3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-ethyl-6-methylpyridin-2(1H)-one::3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino}-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL268871::L-697,661::Pyridinone deriv.

SMILES CCc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C

InChI Key InChIKey=WHFRDXVXYMGAJD-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 1317   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  150nMAssay Description:Compound was tested for Inhibition of HIV-1 RT activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  20nMAssay Description:Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM1317(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed